Prediction of Passive Membrane Permeability of Linagliptin

Linagliptin is a highly selective inhibitor of dipeptidyl peptidase-4 and therefore clinically utilized to treat adults with type 2 diabetes mellitus. The objective this study was predict how the ions normally found in extracellular or intracellular fluids within body system will influence linagliptin’s rate passive diffusion across cell membrane. methodology involved measuring linagliptin partition coefficient chloroform-water containing salts at 25 oC by shake flask method. results indicate that highest concentration (0.5 M) studied, sodium chloride give value when compared control. In conclusion, physiological would have little no effect on drug’s molecular state fluid as failed significantly alter drug, hence not membrane permeability linagliptin.